Our research is broadly concerned with understanding and exploiting non-covalent protein-ligand and protein-protein molecular recognition. We employ a question-driven, multi-disciplinary approach that combines chemical, biophysical and structural techniques with the concepts of fragment-based ligand design. The ultimate aim is to elucidate cellular mechanisms at the molecular level and to rationally design novel chemical probes of biological systems.

Current research efforts are directed towards:

- interrogating druggability of native protein interfaces within multi-subunit protein complexes;

- engineering protein interfaces for the selective chemical intervention on biological function;

- developing new methods for fragment-based ligand design.